List of supplements that interact with CYP3A4 and P-glycoprotein enzymes
List of supplements that interact with CYP3A4 and P-glycoprotein enzymes
Based on the provided search results, here is a list of supplements that are known to inhibit CYP3A4 and/or P-glycoprotein:
CYP3A4 Inhibitors:
Echinacea purpurea
Ginkgo biloba (EGb 761)
St. John’s Wort (Hypericum perforatum)
Garlic (Allium sativum)
Green tea (Camellia sinensis)
Grapefruit (Citrus paradisi)
Pomegranate (Punica granatum)
Turmeric (Curcuma longa)
Ginger (Zingiber officinale)
Cinnamon (Cinnamomum verum)
Clove (Syzygium aromaticum)
Sage (Salvia officinalis)
Thyme (Thymus vulgaris)
P-Glycoprotein Inhibitors:
Echinacea purpurea
Ginkgo biloba (EGb 761)
St. John’s Wort (Hypericum perforatum)
Garlic (Allium sativum)
Green tea (Camellia sinensis)
Grapefruit (Citrus paradisi)
Pomegranate (Punica granatum)
Turmeric (Curcuma longa)
Ginger (Zingiber officinale)
Cinnamon (Cinnamomum verum)
Clove (Syzygium aromaticum)
Sage (Salvia officinalis)
Thyme (Thymus vulgaris)
EGb 761 (Ginkgo biloba extract)
Both CYP3A4 and P-Glycoprotein Inhibitors:
Echinacea purpurea
Ginkgo biloba (EGb 761)
St. John’s Wort (Hypericum perforatum)
Garlic (Allium sativum)
Green tea (Camellia sinensis)
Grapefruit (Citrus paradisi)
Pomegranate (Punica granatum)
Turmeric (Curcuma longa)
Ginger (Zingiber officinale)
Cinnamon (Cinnamomum verum)
Clove (Syzygium aromaticum)
Sage (Salvia officinalis)
Thyme (Thymus vulgaris)
Please note that this list is not exhaustive and is based on the provided search results. Additionally, the inhibition of CYP3A4 and P-glycoprotein by these supplements may vary depending on the individual, dose, and duration of supplementation. It is essential to consult with a healthcare professional before taking any supplements, especially if you are taking medications or have underlying medical conditions.
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Context
Herbal or Natural Supplements Known to Inhibit Cytochrome P450 (CYP) 3A4
Drug Development and Drug Interactions | Table of Substrates, Inhibitors and Inducers | FDA
Drug Interactions with CYP3A4: An Update
Cytochrome P450 enzyme mediated herbal drug interactions (Part 1) - PMC
Drug Metabolism - The Importance of Cytochrome P450 3A4
Follow up
ebmconsult.com› articles › herbal-natural-medicines-inhibitors-cyp3a4-enzyme
Herbal or Natural Supplements Known to Inhibit Cytochrome P450 (CYP) 3A4
Many known drug interactions with prescription medications are mediated through CYP3A4. Not only are herbal or natural medicines also on the rise, but the identification of natural medicines that are known inhibitors of CYP3A4 are also increasing in number.
Drug Development and Drug Interactions | Table of Substrates, Inhibitors and Inducers | FDA
Table of Substrates, Inhibitors and Inducers (including: CYP Enzymes, Clinical index drugs, transporters, and examples of clinical substrates, inhibitors, and inducers).
ncbi.nlm.nih.gov› pmc › articles › PMC4463967
Cytochrome P450 enzyme mediated herbal drug interactions (Part 1) - PMC
It is well recognized that herbal supplements or herbal medicines are now commonly used. As many patients taking prescription medications are concomitantly using herbal supplements, there is considerable risk for adverse herbal drug interactions. Such ...
pubs.acs.org› doi › 10.1021 › acs.jafc.2c00237
CYP3A4 is the main human enzyme responsible for phase I metabolism of dietary compounds, prescribed drugs and xenobiotics, steroid hormones, and bile acids. The inhibition of CYP3A4 activity might impair physiological mechanisms, including the endocrine system and response to drug admission.
CYP3A4 & CYP2D6 Enzyme Inhibitors & Inducers | The Life Raft Group
July 9, 2018 - Note: This page is for educational ... While we do make an effort to keep this list updated, it may not be complete. Please refer to a site like CYTOCHROME P450 DRUG INTERACTION TABLE and/or your medication’s prescribing information for more definitive informati...
en.wikipedia.org› wiki › CYP3A4
2 days ago - In 1998, various researchers showed that grapefruit juice, and grapefruit in general, is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability. In some cases, this can lead to a fatal interaction with drugs like astemizole or ...
FunctionEvolutionTissue distributionMechanismsInhibition through fruit ingestionVariabilityInductionTurnoverTechnologyLigandsInteractive pathway map
CYP3A4 Enzyme Roles and Inhibitors: The Grapefruit Effect - SelfDecode Supplements
September 9, 2021 - CYP3A4 clears 45 - 60% of currently prescribed drugs. Click to learn more about this crucial enzyme & factors that increase/decrease it.
medsafe.govt.nz› profs › puarticles › march2014drugmetabolismcytochromep4503a4.htm
Drug Metabolism - The Importance of Cytochrome P450 3A4
Medicines that are potent CYP3A4 inhibitors include (but are not limited to) clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, and verapamil9. Common drug-drug interactions involving CYP3A4 include:
pharmacytimes.com› view › 2008-09-8687
March 8, 2021 - The last in the series of cytochrome P450 enzyme articles ends with the most important enzyme-CYP3A4, which metabolizes approximately half of all the drugs on the market.
ncbi.nlm.nih.gov› pmc › articles › PMC9641194
Selecting a medicine has a significant impact on the quality of therapy including efficacy and safety. P-glycoprotein and CYP3A4 share several common substrates known as bi-substrates. Both play major role in the pharmacokinetics and pharmacodynamics ...
Find elsewhere
en.wikipedia.org› wiki › List_of_cytochrome_P450_modulators
List of cytochrome P450 modulators - Wikipedia
November 12, 2023 - This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes. In alphabetical order. ... "Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES".
List of Herbal cytochrome P450 Inhibitors and InducersSources
pharmacytimes.com› view › drug-interactions-with-cyp3a4-an-update
Drug Interactions with CYP3A4: An Update
March 8, 2021 - Pharmacy Times offers the latest news and insights for the pharmacy professional and solutions that impact the everyday practice of pharmacy.
ncbi.nlm.nih.gov› pmc › articles › PMC4727115
Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements - PMC
The use of botanical dietary supplements has grown steadily over the last 20 years despite incomplete information regarding active constituents, mechanisms of action, efficacy, and safety. An important but underinvestigated safety concern is the potential ...
onlinelibrary.wiley.com› doi › full › 10.1111 › j.1742-7843.2008.00227.x
Abstract: Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigate...
Glycoprotein P Inhibitor - an overview | ScienceDirect Topics
In addition, the compound can stimulate the activity of P-gp ATPase and inhibit cytochrome CYP3A4 to a certain extent [105].Read more ... Patricia P. Martins, ... Zhengrong Cui, in International Journal of Pharmaceutics, 2019 · P-glycoproteins (Pgp) are membrane transporter proteins present ...
go.drugbank.com› categories › DBCAT002647
Cytochrome P-450 CYP3A4 Inhibitors (strong) | DrugBank Online
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ebmconsult.com› articles › medications-inhibitors-cyp3a4-enzyme
What are some common medications classified as weak, moderate and strong inhibitors of CYP3A4?
Of the CYP enzymes, CYP3A4 is not only the most prevalent CYP enzyme in the liver, but is used by more than 50% of medications on the market for their metabolism and elimination from the body.
ncbi.nlm.nih.gov› pmc › articles › PMC4477257
Interactions between CYP3A4 and Dietary Polyphenols - PMC
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds. CYP3A4 is known to be the main enzyme involved in ...